Ameliyat Sonrasi Sag Kalimi Belirleyen Faktorler...

The most important factors affecting long-term survival following the resection of periampullary adenocarcinoma include the site of tumor origin, tumor size, histologic grade, resected lymph node status, and resection margin status. The presence of lymphovascular and perineural invasion also have negative prognostic significance, although to a lesser degree. The most potent negative predictor of long-term survival is the presence of lymph node metastases within the resection specimen. As the ratio of positive nodes to total nodes examined increases, the median and long-term survival rates decrease. Patients who undergo an R0 resection for pancreatic malignancy who have the most favorable tumor characteristics—size less than 3 cm, well-differentiated tumors, and an absence of nodal metastasis—have the most favorable outcomes, with a median survival of 4 years and a 5-year survival rate exceeding 40%.